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Tetrahydrofolic acid

产品号 DB00116 公司名称 DrugBank
CAS号 135-16-0 公司网站 http://www.ualberta.ca/
分子式 C19H23N7O6 电 话 (780) 492-3111
分子量 445.42922 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 3

产品价格信息

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产品别名

标题
Tetrahydrofolic acid
IUPAC标准名
(2S)-2-[(4-{[(2-amino-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid
IUPAC传统名
@tetrahydrofolic acid
别名
tetrahydropteroylglutamate
tetrahydropteroyl mono-L-glutamate
tetrahydrafolate
tetra-H-folate
tetrahydrofolate
N-(4-(((2-Amino-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)glutamic acid
H4PteGlu
th-folate
THF
folate-H4
FH4
5,6,7,8-tetrahydrofolic acid
5,6,7,8-tetrahydrofolate
(6S)-tetrahydrofolate

产品登记号

CAS号 135-16-0
PubChem CID 91443
PubChem SID 46504756

产品性质

疏水性(logP) -2.7

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved; nutraceutical
Description Tetrahydrofolic acid is a folic acid derivative. It is produced from dihydrofolic acid by dihydrofolate reductase.
It is converted into 5,10-methylenetetrahydrofolate by serine hydroxymethyltransferase. It is a coenzyme in many reactions, especially in the metabolism of amino acids and nucleic acids. It acts as a donor of a group with one carbon atom. It gets this carbon atom by sequestering formaldehyde produced in other processes.
Indication For nutritional supplementation, also for treating dietary shortage or imbalance.
Pharmacology Tetrahydrofolate is the main active metabolite of dietary folate. It is vital as a coenzyme in reactions involving transfers of single carbon groups. Tetrahydrofolate has a role in nucleic and amino acid synthesis. As nucleic and amino acid synthesis is affected by a deficiency of tetrahydrofolate, actively dividing and growing cells tend to be the first affected. Tetrahydrofolate is used to treat topical sprue and megaloblastic and macrocytic anemias, hematologic complications resulting from a deficiency in folic acid.
Affected Organisms
Humans and other mammals
External Links
Wikipedia

参考文献