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L-Histidine

产品号 DB00117 公司名称 DrugBank
CAS号 71-00-1 公司网站 http://www.ualberta.ca/
分子式 C6H9N3O2 电 话 (780) 492-3111
分子量 155.15456 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 4

产品价格信息

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产品别名

标题
L-Histidine
IUPAC标准名
(2S)-2-amino-3-(1H-imidazol-5-yl)propanoic acid
IUPAC传统名
L-histidine
别名
(S)-4-(2-Amino-2-carboxyethyl)imidazole
(S)-a-Amino-1H-imidazole-4-propanoic acid
(S)-alpha-Amino-1H-imidazole-4-propionic acid
(S)-Histidine
Glyoxaline-5-alanine
Histidine
L-(-)-Histidine

产品登记号

CAS号 71-00-1
PubChem CID 6274
PubChem SID 46507001

产品性质

疏水性(logP) -3.4
溶解度 Not AvailableSoluble

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved; nutraceutical
Description An essential amino acid that is required for the production of histamine. [PubChem]
Indication The actions of supplemental L-histidine are entirely unclear. It may have some immunomodulatory as well as antioxidant activity. L-histidine may be indicated for use in some with rheumatoid arthritis. It is not indicated for treatment of anemia or uremia or for lowering serum cholesterol.
Pharmacology Is found abundantly in hemoglobin; has been used in the treatment of rheumatoid arthritis, allergic diseases, ulcers and anemia. A deficiency can cause poor hearing.
Toxicity ORL-RAT LD50 > 15000 mg/kg, IPR-RAT LD50 > 8000 mg/kg, ORL-MUS LD50 > 15000 mg/kg, IVN-MUS LD50 > 2000 mg/kg; Mild gastrointestinal side effects.
Affected Organisms
Humans and other mammals
Absorption Absorbed from the small intestine via an active transport mechanism requiring the presence of sodium.
External Links
Wikipedia
PDRhealth

参考文献