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Pyruvic acid

产品号 DB00119 公司名称 DrugBank
CAS号 127-17-3 公司网站 http://www.ualberta.ca/
分子式 C3H4O3 电 话 (780) 492-3111
分子量 88.06206 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 6

产品价格信息

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产品别名

标题
Pyruvic acid
IUPAC标准名
2-oxopropanoic acid
IUPAC传统名
pyruvic acid
别名
2-Oxopropanoate
2-Oxopropanoic acid
2-Oxopropionic acid
a-Ketopropionic acid
Acetylformic acid
BTS
Pyroracemic acid
Pyruvate

产品登记号

CAS号 127-17-3
PubChem CID 1060
PubChem SID 46505692

产品性质

疏水性(logP) -0.5
溶解度 1000 mg/mL at 20 oC [YALKOWSKY,SH & DANNENFELSER,RM (1992)]

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved; nutraceutical
Description An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
Indication For nutritional supplementation, also for treating dietary shortage or imbalance
Pharmacology Pyruvic acid or pyruvate is a key intermediate in the glycolytic and pyruvate dehydrogenase pathways, which are involved in biological energy production. Pyruvate is widely found in living organisms. It is not an essential nutrient since it can be synthesized in the cells of the body. Certain fruits and vegetables are rich in pyruvate. For example, an average-size red apple contains approximately 450 milligrams. Dark beer and red wine are also rich sources of pyruvate. Recent research suggests that pyruvate in high concentrations may have a role in cardiovascular therapy, as an inotropic agent. Supplements of this dietary substance may also have bariatric and ergogenic applications.
Toxicity Those taking large doses of supplemental pyruvate—usually greater than 5 grams daily—have reported gastrointestinal symptoms, including abdominal discomfort and bloating, gas and diarrhea. One child receiving pyruvate intravenously for restrictive cardiomyopathy died.
Affected Organisms
Humans and other mammals
Biotransformation In the liver, pyruvate is metabolized via several pathways.
Absorption Pyruvate is absorbed from the gastrointestinal tract from whence it is transported to the liver via the portal circulation.
External Links
Wikipedia
PDRhealth

参考文献